DNA Damage and Repair in Cancer

Call for Papers

Cancer is tightly associated with genome instability caused by DNA damage by carcinogens and ionizing radiation, mutations of genes involved in DNA repair system, the activation of transposable elements, oxidative stress, aging, and other reasons. Better understanding of these mechanisms and of the molecular changes responsible for alterations in the control of genome integrity may help find new targets for cancer therapy. Putting together experimental biological, medical, and bioinformatic data will make it possible to create integral models of cancer development under different conditions, such as environmental, inheritable. and age-related factors.

We invite authors to contribute original research papers as well as review articles that will stimulate the continuing efforts to understand the molecular basis of changes in DNA repair systems and of maintaining genetic instability in cancer. We are interested in articles that explore aspects of disease-associated genome flexibility in humans and also in animal models.

We welcome articles describing new models of cancer progression supported by bioinformatic analysis of experimental data, advances in molecular genetics and molecular diagnostics, new insights into genome instability-linked diseases using animal models, and current concepts in the treatment of cancer using genome stabilization strategies. Potential topics include, but are not limited to:

• Development and testing of novel and effective methods and models for assessing genomic stability and DNA repair in organisms, tissues, and cultured cells
• Development of large-scale bioinformatic strategies to simulate the impact of genetic changes on cancer progression
• Elucidating the mechanisms of maintaining genome integrity in health and disease
• Identification and/or systematization of genomic rearrangements associated with cancer
• Identifying biomarkers/correlates of particular states of genome instability in cancer
• Activity of transposable elements in cancer
• Inheritable factors and genome instability
• Environmental and medical factors influencing DNA integrity
• Aging and genome rearrangements in cancer
• Genome stabilization as the therapeutic strategy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijg/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ijg/repa/ according to the following timetable:

Lead Guest Editor

• Anton A. Buzdin, Group for Genomic Analysis of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

Guest Editors

• Olga Kovalchuk, Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K3M4
• Andreyan Osipov, Laboratory for Radiation Biophysics, Burnazyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow 123098, Russia
• Olga Martin, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 8006, Australia