Drug-Related Genomics in Cancer and Immunological Diseases
1Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China
2State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China
3Institut Pasteur of Shanghai, Chinese Academy of Sciences, No. 411, Hefei Road South, Shanghai 200025, China
4Department of Pharmacology, First Faculty of Medicine, Charles University in Prague, Albertov 4, 12800 Prague, Czech Republic
Drug-Related Genomics in Cancer and Immunological Diseases
Description
Drug-related genes are defined as the genes which encode enzymes, transporters, and targets related to drug absorption, distribution, metabolism, and excretion. The specific topic drug-related genomics in cancer and immunological diseases includes three fields: (1) comparative genomics and molecular evolution study on drug-related genes; (2) pharmacogenomics study on the relationship between drug-related genes mutations and drug effect or safety in the body; (3) the relationship between drug-related genes mutations and human disease susceptibility, diagnosis, development, and prognosis. Cancer is commonly defined as a “disease of the genes,” which is a failure of tissue growth regulation. Immunological diseases such as allergy and autoimmune diseases are also associated with cells and molecules genomics disorder such as disorder of NK cells, mast cells, and cytokines. The studies on drug-related genomics in cancer and immunological diseases could enhance the understanding of the role of drug-related genes in the occurrence and development of cancer or immunological diseases. Pharmacogenomics research can help clinicians predict the efficacy of drugs in the body and avoid some side effects.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand those drug-related genes and their relationship with drug response. Potential topics include, but are not limited to:
- Comparative genomics and biological evolution of drug-related genes
- Pharmacogenomics of drug-related enzymes, transporters, and targets involved in drug absorption, distribution, metabolism, and excretion
- Polymorphisms of drug-related genes with human disease susceptibility, diagnosis, development, and prognosis
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