Early Hepatocellular Carcinoma: Transplantation versus Resection: The Case for Liver Resection

Table 1

Series comparing RSX and LT for HCC on cirrhosis.

First author [ref]	Year	N; RSX	N; LT	Mb (%) RSX	Mb (%) LT	Mt (%) RSX	Mt (%) LT	Overall 5-YS; RSX	Overall 5-YS; LT	Rec (%) RSX	Rec (%) LT
Iwatsuki^wi/o [46]	1991	17**	71**	NR	NR	NR	NR	0%	41%	50	43
Ringe^wi/o [47]	1991	131**	61**	NR	NR	15^30-d,∗	15^30-d,∗	36%	15%	NR	NR
Vargas^wi [48]	1995	35	11	NR	NR	NR	NR	58% 1-YS	81% 1-YS	40	0
Tan^wi/o [49]	1995	12	15	33^NR	13^NR	8.3^NR	6.7^NR	33% 3-YS	63% 3-YS	45	15
Michel^wi/o [50]	1997	102	113	39^NR	38^NR	8.8^NR	22^NR	31%	32%	86	30
Philosophe^wi/o [51]	1998	67**	58**	NR	NR	44^30-d	13^30-d	38%	45%	55	20
Colella^wi/o [52]	1998	41	55	NR	NR	NR	NR	44%	68%	NR	NR
Mazziotti^NR [53]	1998	238	41	42^NR	80^NR	4.6^30-d	6.2^30-d	41%	69%	NR	NR
Otto^wi/o [54]	1998	52	50	NR	NR	21^30-d	8.0^30-d	37%	44%	21	8.0
Weimann^NR [55]	1999	32	31	NR	NR	13^30-d	10^30-d	34%	63%	19	0
Yamamoto^wi/o [25]	1999	294	270	NR	NR	1.4^30-d	7.8^30-d	47%	54%	NR	NR
Llovet^wi [19]	1999	77	87	NR	NR	3.9^90-d	2.3^90-d	51%	69%	57	3.4
Figueras^wi/o [56]	2000	35	85	NR	6.7^NR	NR	NR	51%	60%	65	7.0
De Carlis^wi/o [57]	2001	131	91	NR	NR	4.5^90-d	18^90-d	38%	65%	62	7.0
Shabahang^NR [58]	2002	44	65	NR	NR	7.0^NR	7.0^NR	57% 3-YS	66% 3-YS	NR	NR
Bigourdan^wi [59]	2003	20	17	30^30-d	47^30-d	5.0^30-d	0^30-d	36%	71%	30	18
Pierie^NR [60]	2005	81	33***	NR	NR	20^30-d	9.0^30-d	10%	19%	NR	NR
Margarit^wi [61]	2005	37	36	NR	NR	2.7^30-d	5.6^30-d	78%	50%	59	11
Poon^wi [62]	2007	204	43	35^30-d	44^30-d	3.4^H	0^H	68%	81%	NR	NR
Cillo^wi/o [63]	2007	131	40	NR	NR	5.3^90-d	7.5^90-d	31%	63%	53	5.0
Del Gaudio^wi [22]	2008	80	293	NR	79^NR	0^NR	5.0^NR	66%	58%	59	46
Bellavance^wi [64]	2008	245	134	49^30-d	65^30-d	1.6^30-d	1.5^30-d	46%	66%	50	14
Sotiropoulo^wi/o [65]	2009	61	60	38^30-d	38^30-d	23^30-d	8.0^30-d	23%	59%	NR	NR
Zhou^wi [66]	2010	1018	89	NR	NR	0.69^NR	4.5^NR	70%	89%	NR	NR

Abbreviations: RSX: resection; LT: liver transplantation; YS: year-survival; Mb: morbidity; MT: mortality; Rec: recurrence.
*RSX and LT combined.
**Cirrhotic and noncirrhotic livers combined.
***33 wait-list patients (22 transplanted patients).
^wiAll patients within Milan criteria.
^wi/oSome patients within and some outside of Milan criteria.
^NRMilan criteria not reported.
^HHospital mortality (during same admission for same treatment).