Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients

Table 5

Pharmacokinetic parameters of the major echinocandins in clinical use*.

Agent	𝐶max	𝑡1/2	𝑉𝑑	AUC	𝐶𝑡	FeU	FeS
Caspofungin	7.64	10	0.4	88–115	0.15	1.40%	35%
Micafungin	4.95	14	0.23	111	0.19	0.70%	40%
Anidulafungin	2.07–3.5	25	0.5	44–53	0.26	<1%	30%, <10% unchanged

*Dose 50 mg single dose, 𝐶_max: maximum concentration, 𝑡_1/2: elimination half-life, 𝑉_𝑑: volume of distribution, AUC: area under the plasma concentration and time curve, 𝐶_𝑡: total clearance, FeU: fraction excreted in urine, FeS: fraction excreted in stool.