Review Article

Surgical Treatment of Neuroendocrine Liver Metastases

Table 1

Case series of hepatic resections performed for neuroendocrine liver metastases published in the past 15 years. The following table summarizes the results of modern-day series of liver resections performed for neuroendocrine tumors liver metastases.

AuthorYear undergoing resectionPercentage of curative and palliative resectionsOperative mortality (%)Operative morbidity (%)Symptom control (%)Survival (% is for 5-year survival if not otherwise stated)

(1)Que et al. [13]19957438% curative
62% palliative
2.7249073% at 4 years
Similar survival rates between curative versus palliative resection
(2)Dousset et al. [35]19961771% curative,
29% palliative
5.923.58846% at 5 years (overall)
62% at 5 years (curative)
(3)Ahlman et al. [16]19965422% curative,
78% palliative
0NA10070% at 5 years
(4)Chen et al. [26]199715100% curative0NANA73% at 5 years
(5)Chamberlain et al. [23]20003444% curative,
56% palliative
6NA10076% at 5 years
Differences in survival between curative/palliative resections are not reported
(6)Grazi et al. [30]20001984% curative,
16% palliative
0NANA92.6% at 4 years
(7)Sarmiento et al. [19]200117044% curative,
56% palliative
1.24.19661% at 5 years;
35% at 10 years
Differences in survival between curative and palliative resections are not reported
(8)Yao et al. [32]200116100% curative012NA70% at 5 years
(9)Coppa et al. [36]200120100% curativeNANANA67% at 5 years
(10)Jaeck et al. [103]200113NA0NA10068% at 6 years
(11)Nave et al. [33]20013132% curative,
68% palliative
013NA47% at 5 years
86% for curative resections, 26% for palliative resections
(12)Dejong et al. [104]20025NA020NAMedian survival 59 months
(13)Norton et al. [28]200316100% curative01910082% at 5 years
(14)Elias et al. [29]20034753% curative,
47% palliative
545NA71% at 5 years
Similar survival rates between curative versus palliative resection
(15)Osborne et al. [54]20066162% curative,
28% palliative
03.29180% at 5 years (curative)
60% at 5 years; (palliative)
(16)Reddy et al. [41]20063370% curative,
30% palliative
942NA75% at 3 years;
Differences in survival between curative and palliative resections are not reported
(17)Hibi et al. [43]200621100% curative01910041% at 5 years
(18)House et al. [37]200626100% curative0NANAMedian survival 78 months
(19)Gomez et al. [34]20071883% curative,
17% palliative
5.52210086% at 5 years
Differences in survival between curative and palliative resections are not reported
(20)Landry et al. [105]200823NA026NA75% at 5 years
(21)Chambers et al. [106]200830NA0228674% at 5 years
(22)Ahmed et al. [107]200950NA0NANA74.3% at 5 years

Comments: Operative mortality and morbidity refer to figures for patients undergoing liver resections. Survival date is stated for the entire cohort (curative and palliative resections), unless otherwise is stated. Symptom control includes both partial and complete response. NA means that information was not provided in original paper.