EGFR induced signaling pathways. The major source of each EGFR ligands involved in liver regeneration is schematized. Amphiregulin liver induction right after PH is not sufficient to determine the cellular origin of this secretion. Upon binding of its ligands, EGFR homodimerizes leading to phosphorylation of many tyrosine residues localized in the carboxy-terminal tail of EGFR. Phospho-EGFR is then able to recruit adaptor proteins. They transduce the EGFR signaling by inducing several EGFR-dependent pathways, including the RAS-MAPkinase, PI3K-AKT, PLCγ, and Stat pathways. Collectively these pathways control proliferation, differentiation, migration, and survival of the cell.