Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status
Table 3
Site of EHPM and viral infection status.
Site of EHPM (histology)
HCV Ab (+)/HBs Ag (−)
HCV Ab (−)/HBs Ag (+)
HCV Ab (+)/HBs Ag (+)
HCV Ab (−)/HBs Ag (−)
Total (patients)†
P value
n = 50 (%)
n = 9 (%)
n = 2 (%)
n = 13 (%)
n = 74 (%)
Gastric (ad)
27 (54.0)
2 (22.2)
0
3 (23.1)
32 (43.2)
0.0424
Head and neck (scc)‡
4 (8.0)
1 (11.1)
0
1 (7.7)
6 (8.1)
0.9538
Urinary tract (uc)§
2 (4.0)
4 (44.4)
0
0
6 (8.1)
0.0002
Prostate (ad)
3 (6.0)
0
1 (50.0)
2 (15.4)
6 (8.1)
0.1018
Breast (dc)
1 (2.0)
0
0
4 (30.8)
5 (6.8)
0.0023
Colorectal (ad)
3 (6.0)
1 (11.1)
0
1 (7.7)
5 (6.8)
0.8893
Kidney (rcc)
1 (2.0)
0
1 (50.0)
1 (7.7)
3 (4.1)
0.1502
Extrahepatic biliary tract (ad)¶
1 (2.0)
0
0
1 (7.7)
2 (2.7)
0.6548
Skin (scc)
2 (4.0)
0
0
0
2 (2.7)
0.8048
B-cell lymphoma
2 (4.0)
0
0
0
2 (2.7)
0.8048
Uterus (unknown)
2 (4.0)
0
0
0
2 (2.7)
0.8048
Pancreas (dc)
1 (2.0)
0
0
0
1 (1.4)
0.9221
Lung (ad)
1 (2.0)
0
0
0
1 (1.4)
0.9221
Leukemia
0
1 (11.1)
0
0
1 (1.4)
0.0548
†Each malignancy in multiple EHPM case is separately counted. ‡Four cases of esophagus, one case of larynx and one case of oral. §Five cases of bladder and one case of ureteral. ¶One case of gallbladder and one case of bile duct. ad: Adenocarcinoma, scc: Squamous cell carcinoma, uc: Urothelial carcinoma, dc: Ductal carcinoma, rcc: Renal cell carcinoma.
