Table 1: Evaluation of serum alpha fetoprotein as a marker of circulation tumor cell in different hepatocellular carcinoma studies. nRT-PCR, nested RT-PCR; qRT-PCR, quantitative RT-PCR.

AuthorPCRSensitivityCasesSamplesPositivityPredictability of recurrence

[55]qRT-PCR1 CHC/10737
136
Blood
BM
18%
28%
No
Yes
[64]qRT-PCR1 CHC/106 38
25
Blood
BM
10%
48%
Yes
No
[56]nRT-PCR5 cells/1 mL24Blood
BM
29%
43%
Suspect
[54]Competitive RT10 cells/9 mL22
11
Blood
BM
26%
45%
NA
[90]RT-PCRNA18BM93%No
[61, 62]nRT-PCR33Blood52%Extrahepatic metastases
[57]nRT-PCR15 cells/mL64Blood36%Extrahepatic metastases
[58]nRT-PCR1CHC/105 mono20Blood25%No
[91]nRT-PCR10−6μg/μL of RNA33Blood54%Yes
[92]nRT-PCR1CHC/105 mono87Blood36%Yes
[93]nRT-PCR1 CHC/107 mono85Blood26–45%No
[88]RT-PCR1 CHC/10652Blood25%No