Review Article
Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again
Table 1
Various proposed criteria for the selection of HCC patients waiting for liver transplantation.
| | Author (year), abbreviation | Criteria |
| | Only radiological criteria |
| | Mazzaferro [52], Milan | 1 HCC ≤5 cm or ≤3 HCC ≤3 cm | | Yao [53], UCSF | 1 HCC ≤6.5 cm or ≤3 HCC ≤4.5 cm with TTD ≤8 cm | | Herrero [54], CUN | 1 HCC ≤6 cm or ≤3 HCC ≤5 cm | | Onaca [55], Dallas | 1 HCC ≤6 cm or ≤4 HCC ≤5 cm | | Sugawara [56], Tokyo | ≤5 HCC ≤5 cm | | Lee [57], Asan | ≤6 HCC ≤5 cm | | Silva [58], Valencia | ≤3 HCC ≤5 cm with TTD ≤10 cm | | Toso [59], TTV | TTV ≤115 cm3 | | Mazzaferro [60], Up-to-seven | Number + maximum size of HCC = 7 | | Fan [61], Shanghai | 1 HCC ≤9 cm or ≤3 HCC ≤5 cm with TTD ≤9 cm |
| | Criteria needing preoperative biopsy |
| | Cillo [62], Padua | Tumor grading I or II | | Zheng [63], Hangzhou | TTD ≤8 cm or HCC grading I or II and AFP ≤400 ng/mL |
| | Combined radiological and biological criteria |
| | Kwon [64], Seoul | HCC ≤5 cm (no number restriction) and AFP ≤400 ng/mL | | Takada , Ito [65, 66], Kyoto | ≤10 HCC ≤5 cm and DCP ≤400 mAU/mL | | Toso et al. [33], TTV/AFP | TTV ≤115 cm3 and AFP ≤400 ng/mL | |
Lai et al. [67], TTD/AFP | TTD ≤8 cm and AFP ≤400 ng/mL |
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HCC: hepatocellular carcinoma; TTD: total tumor diameter; TTV: total tumor volume; AFP: alpha foetoprotein; DCP: des-γ-carboxy prothrombin.
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