Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis

<table>Normal hepatic methionine metabolism. 5-MTHF: 5-methyltetrahydrofolate; THF: tetrahydrofolate; MS: methionine synthase; BHMT: betaine hydroxy methyltransferase; DMG: dimethylglycine; MAT: methionine adenosyl transferase; SAM: S-adenosylmethionine; MT: methyltransferase; PE: phosphatidylethanolamine; PEMT: phosphatidylethanolamine  methyltransferase; PC: phosphatidylcholine; SAH: S-adenosylhomocysteine; SAHH: SAH hydrolase; C<i>β</i>S: cystathionine beta synthase; ABU: <i>α</i>-aminobutyrate; GSH: glutathione.</table>

International Journal of Hepatology

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Figure 1

Figure 1: Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis 