Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma

Figure 5

Everolimus/patupilone combination induced cell apoptosis and exerted antiangiogenic effect in HCC models. Tumor xenografts were harvested, fixed, and stained for cleaved PARP and CD34 by immunohistochemistry. Representative images (400x magnification) were shown. Quantitation of cleaved PARP and CD34 (microvessel density, MVD) staining was shown in (b) (𝑛=10 per group, *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 versus vehicle group).

(a)

(b)