Pretreatment of Small-for-Size Grafts In Vivo by γ-Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation

Figure 1

Survival curves, histopathological findings from HE staining, and graft damage scores. (a) Survival curves after SOLT with a 40%-SFSG. There were significant differences between laparotomy and SOLT with saline (𝑃<0.05*) and between SOLT with saline and SOLT with GABAR agonist (𝑃<0.05^†). (b) Laparotomy with saline: H-E, ×100. (c) SOLT with saline: H-E, ×100. (d) SOLT with GABAR agonist: H-E, ×100. (e) Graft damage score: There were significant differences between laparotomy and SOLT with saline (𝑃<0.05*) and between SOLT with saline and SOLT with GABAR agonist (𝑃<0.05^†). GABAR, γ-aminobutyric acid receptor; HE, hematoxylin-eosin; HV, hepatic vein; PV, portal vein; SFSG, small-for-size graft; and SOLT, split orthotopic liver transplantation.

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