Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context
Figure 3
HCA on the background of NASH. (a) A woman born in 1956. Several nodules in the liver, largest 8 cm. Oral contraceptives for 31 years; BMI 24.6. Surgery in 2007 (several tumorectomies and segmentectomies). H&E: IHCA (typical expression of SAA and CRP—not shown), very mild steatosis, contrasting with highly steatotic (60%) nontumoral liver (NT): NASH with mild activity, without fibrosis. (b-c) Woman born in 1973, metabolic syndrome (noninsulin-dependant diabetes, hypercholesterolemia, hypertriglyceridemia). Oral contraceptives 15 years, BMI 31.6. Two liver nodules, largest 26 mm in segment IV. Segmentectomy IVB plus radio frequency of the other nodule (1 cm) in segment VIII. (b) H&E: nonsteatotic HCA (without immunohistochemical characteristics), classified as UHCA; its limit contrast with severe steatotic non tumoral liver (NT). (c) H&E: nontumoral liver: NASH with severe steatosis (80%), mild activity, and septal fibrosis (stage 3).
