Research Article

Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification

Box 1

Clinical and pathological information useful to manage the patient.
Age, sex
Mode of discovery: emergency, pain, behavior after stopping (or not) OC
Number of nodules, max size, location
Radiological diagnosis: FNH, HCA, HCC, MRN, cannot differentiate
Woman: oral contraception (age beginning, stop), duration, type
   Number of children (age)
Drugs including all types of hormones particularly male, antiepileptic
Habit: alcohol, tobacco
Diseases
   BMI, metabolic syndrome, NASH
   Diabetes, MODY3 (family history)
   Glycogenosis, deficit OTC
   Mc Cune Albright
   FAP
   Vascular diseases
      Congenital malformations, BCS, HPS,
   Biliary diseases: CHF, polycystic kidney diseases
   POCS
   Brain tumor
Family history of liver tumors
Pathological diagnosis
   Biopsy, surgical specimen (safety margin)
   Biopsy: quality
   HCA: H-HCA, IHCA, β-HCA, β-IHCA, UHCA
   HCC
   HCA borderline lesion; HCA with dysplasia, HCC foci
   FNH
   FNH/UHCA?
   FNH
   MRN/FNH-like
   Association of different types of nodules
   Nontumoral liver
Normal; steatosis, NASH, glycogenosis, vascular liver diseases, biliary disease and so forth