Clinical Study
A Reappraisal of Chemotherapy-Induced Liver Injury in Colorectal Liver Metastases before the Era of Antiangiogenics
Table 3
Histological lesions of the non-tumorous liver parenchyma.
| | Histological lesions of the non-tumorous liver parenchyma | All | Chemo+ ()
(%) | Chemo− ()
(%) | |
| | Steatosis ≤ 30% | 40 (80) | 29 (88) | 11 (65) | NS | | Steatosis > 30% | 2 (4) | 1 (3) | 1 (6) | NS | | Steatohepatitis (NASH), NAS ≥ 5 | 0 (0) | 0 (0) | 0 (0) | — | | Grade II and III sinusoidal dilatation | 18 (36) | 14 (42) | 4 (24) | NS | | Nodular regenerative hyperplasia (NRH) | 6 (12) | 5 (15) | 1 (6) | NS | | Moderate to severe perisinusoidal fibrosis | 7 (14) | 7 (21) | 0 (0) | 0.04 | | Portal fibrosis ≥ F2 | 13 (26) | 10 (31) | 3 (18) | NS | | Mild/severe postoperative lesions | 9 (18)/16 (32) | 7 (21)/12 (36) | 2 (12)/4 (24) | NS/NS |
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