Value and Limits of Routine Histology Alone or Combined with Glutamine Synthetase Immunostaining in the Diagnosis of Hepatocellular Adenoma Subtypes on Surgical Specimens
Table 1
Pathological data of HCA subtypes.
H-HCA ()
IHCA ()
b-IHCA ()
b-HCA ()
UHCA ()
Steatosis
43
17
1
1
2
>60%/30–60%/10–30%
11/19/13
1/8/8
0/0/1
1/0/0
1/1/0
Focal/spread/diffuse
9/22/12
15/2/0
1/0/0
1/0/0
2/0/0
Sinusoidal dilatation
11
40
9
0
3
Major/moderate/mild
0/4/7
12/19/9
3/3/3
0
0/1/2
Focal/spread/diffuse
10/1/0
23/12/5
8/1/0
0
2/1/0
Peliosis
9
10
5
0
3
Pseudo-PT
1
40
6
0
0
Inflammation
0
43
7
1
0
Ductular reaction
0
31
4
0
2
Remodeling
5
7
3
1
3
Cytological abnormalities
2
0
0
0
2
Micro-HCA*
24
16
1
0
0
Others types of nodules
10
4
1
1
0
NTL
Steatosis
2
12
2
0
3
Sinusoidal dilatation
1
6
1
1
2
NASH
0
1
0
0
0
Fibrosis
0
1
2
0
1
Portal embolisation
0
4
1
1
0
HCA: hepatocellular adenoma; H-HCA: HNF1α mutated HCA; IHCA: inflammatory HCA; b-IHCA: β-catenin mutated IHCA; b-HCA: β-catenin mutated HCA; UHCA: unclassified HCA; PT: Portal Tract; *: at distance of main tumor; NASH: non alcoholic steatohepatitis; NTL: non tumoral liver.
