Review Article
Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials
Table 2
Reported biochemistry markers and evidence of hepatotoxicity.
| Laboratory test for screening hepatotoxicity | Number of studies
| % |
| Individual laboratory test | | | AST | 16 | 88.9 | ALT | 15 | 83.3 | ALP | 9 | 50.0 | Total bilirubin | 7 | 38.9 | Reported as liver function tests | 2 | 11.1 | Combined laboratory test | | | AST or ALT | 6 | 33.3 | AST and ALP and total bilirubin | 1 | 5.5 | AST or ALT and ALP | 3 | 16.7 | AST or ALT and total bilirubin | 1 | 5.5 | AST or ALT and ALP and total bilirubin | 5 | 27.8 | Evidence of hepatotoxicity | | | No evidence, or not clinically significant | 10 | 55.6 | Evidence reported, with clinical significance | 8 | 44.4 |
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