Research Article
Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control
Table 1
Effects of boldine (200 μM) on the adenine mononucleotide contents of the livers from fasted rats. The liver perfusion and the analytical procedures were described in the Materials and methods. In control livers, 2 mM L-lactate was infused alone from 10 to 56 minutes; the test livers were perfused with 2 mM lactate from 10 to 36 minutes and with 200 μM boldine from 36 to 56 minutes. At 56 minutes, the livers were freeze-clamped in liquid nitrogen, and the adenine nucleotides were extracted with cold perchloric acid. Values are of 4 to 5 experiments. Asterisks () indicate statistical significance in comparison with the control condition according to the Student-Newman-Keuls post hoc testing ().
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