Characterization of Autoantibodies against the E1𝜶 Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis

Table 3

Clinical statuses of the PBC patients and their antibody binding profiles against each epitope region.

Patient No.

Asymptomatic/Symptomatic

Epitope no.^b

Stage^a

1

2

3

4

5

6

7

8

9

10

11

12

(aa 3143)

(4969)

(7188)

(93104)

(107123)

(134168)

(171188)

(215231)

(233256)

(259266)

(280294)

(311327)

P07

Asymptomatic

1

+++

+

++

+++

+

+++

+

P13

Symptomatic

4

++

+

+

+

+

+++

+++

+

+

++

+

P18

Symptomatic

2

++

+

+

+

++

+++

++

+++

++

+

+

P20

Asymptomatic

ND

+

++

+

+

+

NOTE: ^athe stages were determined according to Scheuer's classification [30].
^bPBC sera with anti-BCOADC-E1a antibodies were analyzed by multipin ELISA. The reactivities against each epitope are summarized.
Symbols represent Z-scores as follows: ++, >3.0; +, 2.0-3.0; , 02.0.
Abbreviations: aa, amino acid; ND, not determined.