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Linked References

1. Y. Iwakiri and R. J. Groszmann, “Vascular endothelial dysfunction in cirrhosis,” Journal of Hepatology, vol. 46, no. 5, pp. 927–934, 2007. View at Publisher · View at Google Scholar · View at Scopus
2. R. J. Groszmann, G. Garcia-Tsao, J. Bosch et al., “Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis,” The New England Journal of Medicine, vol. 353, no. 21, pp. 2254–2261, 2005. View at Publisher · View at Google Scholar · View at Scopus
3. M. Merli, G. Nicolini, S. Angeloni et al., “Incidence and natural history of small esophageal varices in cirrhotic patients,” Journal of Hepatology, vol. 38, no. 3, pp. 266–272, 2003. View at Publisher · View at Google Scholar · View at Scopus
4. G. D'Amico, L. Pagliaro, and J. Bosch, “Pharmacological treatment of portal hypertension: an evidence-based approach,” Seminars in Liver Disease, vol. 19, no. 4, pp. 475–505, 1999. View at Publisher · View at Google Scholar · View at Scopus
5. J. G. Abraldes, C. Villanueva, R. Banares et al., “Hepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy,” Journal of Hepatology, vol. 48, no. 2, pp. 229–236, 2008. View at Publisher · View at Google Scholar · View at Scopus
6. J. Bosch, D. Thabut, A. Albillos et al., “Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: a randomized, controlled trial,” Hepatology, vol. 47, no. 5, pp. 1604–1614, 2008. View at Publisher · View at Google Scholar · View at Scopus
7. C. Villanueva, M. Piqueras, C. Aracil et al., “A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding,” Journal of Hepatology, vol. 45, no. 4, pp. 560–567, 2006. View at Publisher · View at Google Scholar · View at Scopus
8. J. Bosch and J. C. Garcia-Pagan, “Prevention of variceal rebleeding,” The Lancet, vol. 361, no. 9361, pp. 952–954, 2003. View at Publisher · View at Google Scholar · View at Scopus
9. G. Garcia-Tsao and J. Bosch, “Management of varices and variceal hemorrhage in cirrhosis,” The New England Journal of Medicine, vol. 362, pp. 823–832, 2010. View at Publisher · View at Google Scholar · View at Scopus
10. G. Garcia-Tsao, A. J. Sanyal, N. D. Grace, and W. Carey, “Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis,” Hepatology, vol. 46, no. 3, pp. 922–938, 2007. View at Publisher · View at Google Scholar · View at Scopus
11. U. Thalheimer, C. Triantos, J. Goulis, and A. K. Burroughs, “Management of varices in cirrhosis,” Expert Opinion on Pharmacotherapy, vol. 12, no. 5, pp. 721–735, 2011. View at Publisher · View at Google Scholar · View at Scopus
12. J. Bosch, A. Berzigotti, J. C. Garcia-Pagan, and J. G. Abraldes, “The management of portal hypertension: rational basis, available treatments and future options,” Journal of Hepatology, vol. 48, supplement 1, pp. S68–S92, 2008. View at Publisher · View at Google Scholar · View at Scopus
13. J. Bosch, “Carvedilol for portal hypertension in patients with cirrhosis,” Hepatology, vol. 51, no. 6, pp. 2214–2218, 2010. View at Publisher · View at Google Scholar · View at Scopus
14. C. Merkel, R. Marin, P. Angeli et al., “A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis,” Gastroenterology, vol. 127, no. 2, pp. 476–484, 2004. View at Publisher · View at Google Scholar · View at Scopus
15. L. L. Gluud, S. Klingenberg, D. Nikolova, and C. Gluud, “Banding ligation versus beta-blockers as primary prophylaxis in esophageal varices: systematic review of randomized trials,” The American Journal of Gastroenterology, vol. 102, no. 12, pp. 2842–2848, 2007. View at Publisher · View at Google Scholar · View at Scopus
16. C. S. Lay, Y. T. Tsai, F. Y. Lee et al., “Endoscopic variceal ligation versus propranolol in prophylaxis of first variceal bleeding in patients with cirrhosis,” Journal of Gastroenterology and Hepatology, vol. 21, no. 2, pp. 413–419, 2006. View at Publisher · View at Google Scholar · View at Scopus
17. J. G. Abraldes, I. Tarantino, J. Turnes, J. C. Garcia-Pagan, J. Rodes, and J. Bosch, “Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis,” Hepatology, vol. 37, no. 4, pp. 902–908, 2003. View at Publisher · View at Google Scholar · View at Scopus
18. R. M. Perez-Ayuso, J. M. Pique, J. Bosch et al., “Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis,” The Lancet, vol. 337, no. 8755, pp. 1431–1434, 1991. View at Publisher · View at Google Scholar · View at Scopus
19. J. C. Garcia-Pagan and J. Bosch, “Endoscopic band ligation in the treatment of portal hypertension,” Nature Clinical Practice Gastroenterology & Hepatology, vol. 2, no. 11, pp. 526–535, 2005. View at Publisher · View at Google Scholar · View at Scopus
20. S. K. Sarin, M. Wadhawan, S. R. Agarwal, P. Tyagi, and B. C. Sharma, “Endoscopic variceal ligation plus propranolol versus endoscopic variceal ligation alone in primary prophylaxis of variceal bleeding,” The American Journal of Gastroenterology, vol. 100, no. 4, pp. 797–804, 2005. View at Publisher · View at Google Scholar · View at Scopus
21. D. G. Koch, M. R. Arguedas, and M. B. Fallon, “Risk of aspiration pneumonia in suspected variceal hemorrhage: the value of prophylactic endotracheal intubation prior to endoscopy,” Digestive Diseases and Sciences, vol. 52, no. 9, pp. 2225–2228, 2007. View at Publisher · View at Google Scholar · View at Scopus
22. S. J. Rudolph, B. K. Landsverk, and M. L. Freeman, “Endotracheal intubation for airway protection during endoscopy for severe upper GI hemorrhage,” Gastrointestinal Endoscopy, vol. 57, no. 1, pp. 58–61, 2003. View at Scopus
23. B. Castaneda, J. Morales, R. Lionetti et al., “Effects of blood volume restitution following a portal hypertensive-related bleeding in anesthetized cirrhotic rats,” Hepatology, vol. 33, no. 4, pp. 821–825, 2001. View at Publisher · View at Google Scholar · View at Scopus
24. R. de Franchis, “Evolving consensus in portal hypertension report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension,” Journal of Hepatology, vol. 43, no. 1, pp. 167–176, 2005. View at Publisher · View at Google Scholar · View at Scopus
25. N. Hilzenrat, A. Arish, A. Yaari, Y. Almog, and E. Sikuler, “Blood viscosity, hemodynamics and vascular hindrance in a rat model of acute controlled bleeding and volume restitution with blood or Haemaccel,” Acta Anaesthesiologica Scandinavica, vol. 45, no. 3, pp. 371–376, 2001. View at Publisher · View at Google Scholar · View at Scopus
26. S. Vivas, M. Rodriguez, M. A. Palacio, A. Linares, J. L. Alonso, and L. Rodrigo, “Presence of bacterial infection in bleeding cirrhotic patients is independently associated with early mortality and failure to control bleeding,” Digestive Diseases and Sciences, vol. 46, no. 12, pp. 2752–2757, 2001. View at Publisher · View at Google Scholar · View at Scopus
27. B. Bernard, J. D. Grange, E. N. Khac, X. Amiot, P. Opolon, and T. Poynard, “Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis,” Hepatology, vol. 29, no. 6, pp. 1655–1661, 1999. View at Publisher · View at Google Scholar · View at Scopus
28. J. Fernandez, L. R. del Arbol, C. Gomez, et al., “Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage,” Gastroenterology, vol. 131, no. 4, pp. 1049–1056, 2006.
29. J. Pohl, K. Pollmann, P. Sauer, A. Ring, W. Stremmel, and T. Schlenker, “Antibiotic prophylaxis after variceal hemorrhage reduces incidence of early rebleeding,” Hepato-Gastroenterology, vol. 51, no. 56, pp. 541–546, 2004. View at Scopus
30. K. Soares-Weiser, M. Brezis, R. Tur-Kaspa, and L. Leibovici, “Antibiotic prophylaxis for cirrhotic patients with gastrointestinal bleeding,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD002907, 2002. View at Publisher · View at Google Scholar
31. M. Bildozola, D. Kravetz, J. Argonz et al., “Efficacy of octreotide and sclerotherapy in the treatment of acute variceal bleeding in cirrhotic patients. A prospective, multicentric, and randomized clinical trial,” Scandinavian Journal of Gastroenterology, vol. 35, no. 4, pp. 419–425, 2000. View at Scopus
32. A. Escorsell, L. R. del Arbol, R. Planas et al., “Multicenter randomized controlled trial of terlipressin versus sclerotherapy in the treatment of acute variceal bleeding: the TEST study,” Hepatology, vol. 32, no. 3, pp. 471–476, 2000. View at Scopus
33. G. Ioannou, J. Doust, and D. C. Rockey, “Terlipressin for acute esophageal variceal hemorrhage,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD002147, 2003. View at Publisher · View at Google Scholar
34. R. de Franchis, “Somatostatin, somatostatin analogues and other vasoactive drugs in the treatment of bleeding oesophageal varices,” Digestive and Liver Disease, vol. 36, supplement 1, pp. S93–S100, 2004. View at Publisher · View at Google Scholar
35. D. A. Corley, J. P. Cello, W. Adkisson, W. F. Ko, and K. Kerlikowske, “Octreotide for acute esophageal variceal bleeding: a meta-analysis,” Gastroenterology, vol. 120, no. 4, pp. 946–954, 2001. View at Scopus
36. R. Banares, A. Albillos, D. Rincon et al., “Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis,” Hepatology, vol. 35, no. 3, pp. 609–615, 2002. View at Publisher · View at Google Scholar · View at Scopus
37. J. C. Garcia-Pagan, K. Caca, C. Bureau et al., “Early use of TIPS in patients with cirrhosis and variceal bleeding,” The New England Journal of Medicine, vol. 362, no. 25, pp. 2370–2379, 2010. View at Publisher · View at Google Scholar · View at Scopus
38. J. C. Garcia-Pagan, F. Feu, J. Bosch, and J. Rodes, “Propranolol compared with propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis. A randomized controlled study,” Annals of Internal Medicine, vol. 114, no. 10, pp. 869–873, 1991. View at Scopus
39. A. T. Blei, D. Ganger, H. L. Fung, and R. Groszmann, “Organic nitrates in portal hypertension,” European Heart Journal, vol. 9, pp. 205–211, 1988. View at Scopus
40. L. L. Gluud, E. Langholz, and A. Krag, “Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices,” Alimentary Pharmacology & Therapeutics, vol. 32, no. 7, pp. 859–871, 2010. View at Publisher · View at Google Scholar · View at Scopus
41. J. Gournay, C. Masliah, T. Martin, D. Perrin, and J. P. Galmiche, “Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding,” Hepatology, vol. 31, no. 6, pp. 1239–1245, 2000. View at Scopus
42. R. de Franchis and M. Primignani, “Endoscopic treatments for portal hypertension,” Seminars in Liver Disease, vol. 19, no. 4, pp. 439–455, 1999. View at Scopus
43. L. Laine and D. Cook, “Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis,” Annals of Internal Medicine, vol. 123, no. 4, pp. 280–287, 1995. View at Scopus
44. G. H. Lo, W. C. Chen, C. K. Lin et al., “Improved survival in patients receiving medical therapy as compared with banding ligation for the prevention of esophageal variceal rebleeding,” Hepatology, vol. 48, no. 2, pp. 580–587, 2008. View at Publisher · View at Google Scholar · View at Scopus
45. D. Patch, C. A. Sabin, J. Goulis et al., “A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis,” Gastroenterology, vol. 123, no. 4, pp. 1013–1019, 2002. View at Publisher · View at Google Scholar · View at Scopus
46. G. Romero, D. Kravetz, J. Argonz et al., “Comparative study between nadolol and 5-isosorbide mononitrate vs. endoscopic band ligation plus sclerotherapy in the prevention of variceal rebleeding in cirrhotic patients: a randomized controlled trial,” Alimentary Pharmacology & Therapeutics, vol. 24, no. 4, pp. 601–611, 2006. View at Publisher · View at Google Scholar · View at Scopus
47. C. Villanueva, J. Minana, J. Ortiz et al., “Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding,” The New England Journal of Medicine, vol. 345, no. 9, pp. 647–655, 2001. View at Publisher · View at Google Scholar · View at Scopus
48. J. de la Pena, E. Brullet, E. Sanchez-Hernandez et al., “Variceal ligation plus nadolol compared with ligation for prophylaxis of variceal rebleeding: a multicenter trial,” Hepatology, vol. 41, no. 3, pp. 572–578, 2005. View at Publisher · View at Google Scholar · View at Scopus
49. G. H. Lo, K. H. Lai, J. S. Cheng et al., “Endoscopic variceal ligation plus nadolol and sucralfate compared with ligation alone for the prevention of variceal rebleeding: a prospective, randomized trial,” Hepatology, vol. 32, no. 3, pp. 461–465, 2000. View at Scopus
50. C. Villanueva, C. Aracil, A. Colomo et al., “Clinical trial: a randomized controlled study on prevention of variceal rebleeding comparing nadolol + ligation vs. hepatic venous pressure gradient-guided pharmacological therapy,” Alimentary Pharmacology & Therapeutics, vol. 29, no. 4, pp. 397–408, 2009. View at Publisher · View at Google Scholar · View at Scopus
51. V. Gulberg, M. Schepke, G. Geigenberger et al., “Transjugular intrahepatic portosystemic shunting is not superior to endoscopic variceal band ligation for prevention of variceal rebleeding in cirrhotic patients: a randomized, controlled trial,” Scandinavian Journal of Gastroenterology, vol. 37, no. 3, pp. 338–343, 2002. View at Publisher · View at Google Scholar · View at Scopus
52. R. Jalan, E. H. Forrest, A. J. Stanley et al., “A randomized trial comparing transjugular intrahepatic portosystemic stent-shunt with variceal band ligation in the prevention of rebleeding from esophageal varices,” Hepatology, vol. 26, no. 5, pp. 1115–1122, 1997. View at Scopus
53. G. Pomier-Layrargues, J. P. Villeneuve, M. Deschenes et al., “Transjugular intrahepatic portosystemic shunt (TIPS) versus endoscopic variceal ligation in the prevention of variceal rebleeding in patients with cirrhosis: a randomised trial,” Gut, vol. 48, no. 3, pp. 390–396, 2001. View at Publisher · View at Google Scholar · View at Scopus