International Journal of Hypertension / 2011 / Article / Tab 3 / Research Article
Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis Table 3 Outcomes of a univariate linear regression analysis with the changes in systolic and diastolic blood pressure at first and last followup compared to baseline (ΔSBP1, ΔDBP1, ΔSBP2, and ΔDBP2, resp.) as dependent variables. Included in the table are all independent variables with a significant
β -coefficient in one of the ΔBP categories or those assumed to be relevant based on the literature. Also shown are the numbers (
) available for the individual analyses.
ΔSBP1 ΔDBP1 ΔSBP2 ΔDBP2 Independent variable β
valueβ
valueβ
valueβ
valueAge (years) −0.750 83 .660 0.030 83 .758 -0.013 102 .937 0.043 102 .689 Sex (1 = female, 2 = male) 4.199 83 .260 3.477 83 .101 -4.737 102 .207 −2.789 102 .251 DM −5.684 78 .202 −0.746 78 .770 −5.896 95 .181 −0.206 95 .943 LVH 2.948 63 .526 2.875 63 .276 −9.461 76 .031 −2.897 76 .343 SBP0 (mmHg) 0.170 83 .083 0.000 83 .994 −0.388 102 <.001 −0.034 102 .608 DBP0 (mmHg) 0.080 83 .572 −0.118 83 .143 −0.378 102 .010 −0.407 102 <.001 Na+ (mmol/L) −0.742 78 .280 −0.825 78 .032 0.600 95 .393 −0.028 95 .951 K+ (mmol/L) 4.206 83 .162 0.341 83 .844 0.017 102 .996 −0.344 102 .867 Na+ /K+ −0.663 78 .038 −0.174 78 .343 −0.123 95 .723 0.035 95 .876 Hb (mmol/L) 6.79 52 .023 2.632 52 .125 −1.837 59 .576 −1.329 59 .529 Ht (%) 162.2 30 .084 56.75 30 .259 −19.98 35 .831 −23.75 35 .707 TC (mmol/L) 5.374 61 .025 2.609 61 .044 −1.555 79 .480 −1.136 79 .424 HDL (mmol/L) 4.880 64 .311 3.639 64 .162 0.283 81 .956 2.826 81 .387 LDL (mmol/L) 5.127 60 .004 2.111 60 .031 0.585 78 .784 −0.291 78 .832 ACR (g/mol) 0.031 40 .518 0.041 40 .170 0.078 45 .036 0.049 45 .028 FU duration (weeks) −0.371 83 .018 −0.150 83 .098 −0.039 102 .001 −0.028 102 <.001 Total DDD 0.503 83 .539 0.348 83 .458 −0.649 102 .435 −0.250 102 .642 DDD ARA 5.446 83 .360 6.501 83 .054 −1.130 102 .847 1.799 102 .634 PAC (pmol/L) 0.001 46 .788 0.003 46 .149 0.002 55 .621 0.004 55 .117 PRC (mU/L) 0.002 47 .553 0.002 47 .325 0.004 56 .392 0.003 56 .225 ARR (pmol/mU) −0.034 46 .094 0.027 46 .020 −0.027 55 .289 0.033 55 .029
(DM: diabetes mellitus; LVH: left ventricular hypertrophy; Na+ : sodium; K+ : potassium; Hb: hemoglobin; Ht: hematocrit; TC: total cholesterol; HDL: high-density lipoprotein; LDL: low-density lipoprotein; ACR: urinary albumin-to-creatinine ratio; FU: followup; DDD: defined daily dose; ARA: aldosterone-receptor antagonist; PAC: plasma aldosterone concentration; PRC: plasma renin concentration; ARR: aldosterone-to-renin ratio).
