Adrenocortical Causes of Hypertension

Table 4

Drug	Class	Usual dose	Comments
Verapamil slow release	Nondihydropyridine calcium channel antagonist	90–120 mg twice daily	Use singly or in combination with the other agents listed in this table.
Hydralazine	Vasodilator	10–12.5 mg twice daily, increasing as required	Commence verapamil slow release first to prevent reflex tachycardia. Commencement at low doses reduces risk of side effects (including headaches, flushing, and palpitations).
Prazosin hydrochloride	α-Adrenergic blocker	0.5–1 mg two to three times daily, increasing as required	Monitor for postural hypotension
Doxazosin mesylate	α-Adrenergic blocker	1–2 mg once daily, increasing as required	Monitor for postural hypotension
Terazosin hydrochloride	α-Adrenergic blocker	1–2 mg once daily, increasing as required	Monitor for postural hypotension