TRC120038, a Novel Dual AT1/ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats
Figure 6
(a) Glomerulus from vehicle-treated ob-ZSF1 rat, showing global glomerulo sclerosis, expansion of mesangial matrix (red arrow), infiltration of foamy macrophage (green arrow), podocyte hypertrophy (yellow arrow), thickening of basement membrane (blue arrow), and complete obliteration of Bowman’s space. PAS staining, 400x (b) Glomerulus from TRC120038-treated ob-ZSF1 rat. (c) Glomerulus from candesartan treated ob-ZSF1 rat, showing normal glomerulus portion with Bowman’s space (black arrow), focal glomerulosclerosis, focal expansion of mesangial matrix with hypercellularity (red arrow), and reduced thickening of basement membrane (blue arrow). PAS staining, 400x.
