Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension

Table 2

Genotype and allele frequencies.

Marker	Genotype frequencies				Allele frequencies
MTHFR C677T	CC	CT	TT	Total	C	T	Total
Case	170 (45.1%)	174 (46.2%)	33 (8.7%)	377	514 (68.2%)	240 (31.8%)	754
Control	175 (44.5%)	183 (46.6%)	35 (8.9%)	393	533 (67.8%)	253 (32.2%)	786
Test statistic	𝜒^2 = 0.03, P = 0.99 (𝛼=0.05)				𝜒^2 = 0.02, P = 0.88 (𝛼=0.05)
MTHFR A1298C	AA	AC	CC	Total	A	C	Total
Case	165 (44.8%)	151 (41.0%)	52 (14.2%)	368	481 (65.4%)	255 (34.6%)	736
Control	162 (42.0%)	173 (44.8%)	51 (13.2%)	386	497 (64.4%)	275 (35.6%)	772
Test statistic	𝜒^2 = 1.10, P = 0.58 (𝛼=0.05)				𝜒^2 = 0.16, P = 0.69 (𝛼=0.05)
MTRR A66G	AA	AG	GG	Total	A	G	Total
Case	103 (28.6%)	192 (53.3%)	65 (18.1%)	360	398 (55.3%)	322 (44.7%)	720
Control	95 (26.5%)	189 (52.8%)	74 (20.7%)	358	379 (52.9%)	337 (47.1%)	716
Test statistic	𝜒^2 = 0.92, P = 0.63 (𝛼=0.05)				𝜒^2 = 0.79, P = 0.37 (𝛼=0.05)
MTHFD1 G1958A	GG	AG	AA	Total	G	A	Total
Case	119 (32.7%)	168 (46.2%)	77 (21.1%)	364	406 (55.8%)	322 (44.2%)	728
Control	104 (28.9%)	183 (50.8%)	73 (20.3%)	360	391 (54.3%)	329 (45.7%)	720
Test statistic	𝜒^2 = 1.73, P = 0.42 (𝛼=0.05)				𝜒^2 = 0.31, P = 0.58 (𝛼=0.05)