Research Article
Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension
Table 3
Genotype and allele frequencies, analysed by gender.
| | Marker | Genotype frequencies | Allele frequencies |
| | MTHFR C677T | CC | CT | TT | Total | C | T | Total |
| | Male | Case | 76 (46.1%) | 75 (45.5%) | 14 (8.5%) | 165 | 227 (68.8%) | 103 (31.2%) | 330 | | Control | 73 (39.9%) | 93 (50.8%) | 17 (9.3%) | 183 | 239 (65.3%) | 127 (34.7%) | 366 | Test statistic
| = 1.35, P = 0.51 () | = 0.95, P = 0.33 () | | Female | Case | 94 (44.3%) | 99 (46.7%) | 19 (9%) | 212 | 287 (67.7%) | 137 (32.3%) | 424 | | Control | 102 (48.6%) | 90 (42.9%) | 18 (8.6%) | 210 | 294 (70%) | 126 (30%) | 420 | | Test statistic | = 0.77, P = 0.68 () | = 0.53, P = 0.47 () |
| | MTHFR A1298C | AA | AC | CC | Total | A | C | Total |
| | Male | Case | 77 (45.8%) | 68 (40.5%) | 23 (13.7%) | 168 | 222 (66.1%) | 114 (33.9%) | 336 | | Control | 86 (47.5%) | 75 (41.4%) | 20 (11%) | 181 | 247 (68.2%) | 115 (31.8%) | 362 | | Test statistic | = 0.57, P = 0.75 () | = 0.37, P = 0.54 () | | Female | Case | 88 (44%) | 83 (41.5%) | 29 (14.5%) | 200 | 259 (64.8%) | 141 (35.3%) | 400 | | Control | 76 (37.1%) | 98 (47.8%) | 31 (15.1%) | 205 | 250 (61%) | 160 (39%) | 410 | | Test statistic | = 2.13, P = 0.35 () | = 1.24, P = 0.27 () |
| | MTRR A66G | AA | AG | GG | Total | A | G | Total |
| | Male | Case | 45 (28.1%) | 81 (50.6%) | 34 (21.3%) | 160 | 171 (53.4%) | 149 (46.6%) | 320 | | Control | 40 (24.2%) | 92 (55.8%) | 33 (20%) | 165 | 172 (52.1%) | 158 (47.9%) | 330 | | Test statistic | χ
2 = 0.93, P = 0.63 () | = 0.11, P = 0.74 () | | Female | Case | 58 (29%) | 111 (55.5%) | 31 (15.5%) | 200 | 227 (56.8%) | 173 (43.3%) | 400 | | Control | 55 (28.5%) | 97 (50.3%) | 41 (21.2%) | 193 | 207 (53.6%) | 179 (46.4%) | 386 | | Test statistic | = 2.29, P = 0.32 () | = 0.77, P = 0.38 () |
| | MTHFD1 G1958A | GG | AG | AA | Total | G | A | Total |
| | Male | Case | 59 (36.9%) | 67 (41.9%) | 34 (21.3%) | 160 | 185 (57.8%) | 135 (42.2%) | 320 | | Control | 48 (28.4%) | 89 (52.7%) | 32 (18.9%) | 169 | 185 (54.7%) | 153 (45.3%) | 338 | | Test statistic | = 4.05, P = 0.13 () | = 0.63, P = 0.43 () | | Female | Case | 60 (29.4%) | 101 (49.5%) | 43 (21.1%) | 204 | 221 (54.2%) | 187 (45.8%) | 408 | | Control | 56 (29.3%) | 94 (49.2%) | 41 (21.5%) | 191 | 206 (53.9%) | 176 (46.1%) | 382 | | Test statistic | = 0.01, P = 0.99 () | = 0.00, P = 0.95 () |
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