Review Article

Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension

Figure 1

The classical RAAS (renal-renin and adrenal aldosterone system) regulates sodium balance via a negative feedback, but the brain RAAS forms a positive feedback cycle to retain more sodium via increased renal SNSA.
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