Review Article

Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension

Figure 2

The most important component of the positive feedback cycle may be the renal nerve because renal nerve ablation lowers blood pressure even in humans, and inhibitors of RAAS lower blood pressure even in low-renin essential hypertensives.
242786.fig.002