The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?

<table>ICV delivery of (pro)renin receptor shRNA reduces brain Ang II level in the hypothalamus. The human renin and AGT double transgenic mice were ICV injected with AAV-PRR short hairpin RNA (AAV-PRR-shRNA, <svg height="16.049999" id="M1" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.212502 16.049999" width="66.212502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> Vg/100nl) or control virus. Two weeks after virus injection, brain tissues were harvested for analysis of Ang II levels in the hypothalamus, cortex, and brainstem. (<svg height="11.225" id="M2" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus AAV-enhanced green fluorescent protein (AAV-eGFP) treatment. </table>

International Journal of Hypertension

fig2

Figure 2

Figure 2: The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? 