Heme Induction with Delta-Aminolevulinic Acid Stimulates an Increase in Water and Electrolyte Excretion

Table 2

Effects of increases in endogenous CO (DALA 80 μmol/Kg, IV) on glomerular filtration rate (GFR), urine flow (UF), sodium excretion (U_NaV), fractional excretion of sodium (FE_Na), and urinary potassium (U_KV).

		UF	GFR	UNaV	FENa	UKV
	𝑁	(μl/min)	(ml/min)	(μmol/min)	(%)	(μmol/min)
No pretreatment
Control	6	6.49±0.47	1.11±0.05	0.59±0.15	0.50±0.03	0.14±0.04
Vehicle	6	6.49±0.48	1.10±0.08	0.61±0.08	0.51±0.16	0.15±0.03
Control	6	6.51±0.50	1.12±0.11	0.60±0.11	0.53±0.12	0.14±0.01
DALA	6	𝟏𝟑.𝟗𝟗±𝟏.𝟖𝟒^∗	1.10±0.06	𝟏.𝟏𝟗±𝟎.𝟎𝟑^∗	𝟎.𝟕𝟖±𝟎.𝟎𝟏^∗	𝟎.𝟗𝟎±𝟎.𝟏𝟑^∗
Chronic L-NAME
Control	6	7.37±0.73	1.11±0.02	0.68±0.13	0.50±0.01	0.23±0.13
Vehicle	6	7.43±0.78	1.15±0.18	0.68±0.04	0.49±0.05	0.23±0.02
Control	6	7.51±0.54	1.12±0.17	0.67±0.11	0.50±0.02	0.24±0.04
DALA	6	𝟏𝟒.𝟑𝟕±𝟎.𝟒𝟏^∗	1.11±0.10	𝟏.𝟐𝟐±𝟎.𝟎𝟐^∗	𝟎.𝟖𝟎±𝟎.𝟏𝟐^∗	𝟏.𝟎𝟗±𝟎.𝟏𝟗^∗