Discovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers

Figure 11

The structures of three IRAP inhibitors from a series of disulfide-cyclized Ang IV peptidomimetics. The ability to inhibit IRAP increases from 10 to 12. Both 11 and 12 have 2000-fold selectivity for IRAP over AP-N.