Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice
Figure 1
Severe aortitis, coronary arteritis and small atherosclerotic lesion on a standard rodent chow diet after 1 year old of HO- mice. (a, g, h) Oil red O staining. (b, c, e, f) Hematoxylin- eosin staining. (d) Elastica Van Gieson staining. (d) Elastic fibers in the vessel walls are torn at the site of severe mononuclear cell infiltration. Magnifications at (a, e) ×40, (b) ×100, (c, d) ×200, and (f, g, h) ×400. Predominant sites of aortitis (b, c, d) and initial fatty streak formation (h) are indicated by arrows. These photomicrographs are representative of numerous sections examined.
