Cardiac-Autonomic Imbalance and Baroreflex Dysfunction in the Renovascular Angiotensin-Dependent Hypertensive Mouse
Figure 5
Relationship between RAS activation, ROS production, and baroreflex dysfunction in the 2K1C mouse. (a) Effects of renal clipping-induced high plasma levels of angiotensin II on peripheral and central neural areas controlling cardiovascular function mediated by reactive oxygen species (ROS); (b) typical flow cytometric analysis with the dihydroethidium assay (DHE) showing elevated production of superoxide in 2K1C mice; (c) comet assay illustrating the detection of greater levels of DNA damage (comet-tail fragmentation) in the 2K1C mice.
