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International Journal of Hypertension
Volume 2013 (2013), Article ID 156179, 7 pages
The Brain-Heart Connection: Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril-Treated Hypertensive Rats—A Bilateral Study
1Unit of Physiology, University of Jaén, 23071 Jaén, Spain
2Institute of Neuroscience “Federico Oloriz”, University of Granada, 18012 Granada, Spain
Received 20 October 2012; Accepted 4 January 2013
Academic Editor: Patrick Vanderheyden
Copyright © 2013 Ana B. Segarra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. F. Thayer and R. D. Lane, “Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration,” Neuroscience and Biobehavioral Reviews, vol. 33, no. 2, pp. 81–88, 2009.
- P. S. Foster and D. W. Harrison, “Magnitude of cerebral asymmetry at rest: covariation with baseline cardiovascular activity,” Brain and Cognition, vol. 61, no. 3, pp. 286–297, 2006.
- M. Ramírez, I. Prieto, F. Vives, M. de Gasparo, and F. Alba, “Neuropeptides, neuropeptidases and brain asymmetry,” Current Protein and Peptide Science, vol. 5, no. 6, pp. 497–506, 2004.
- A. B. Segarra, I. Prieto, I. Banegas et al., “Asymmetrical effect of captopril on the angiotensinase activity in frontal cortex and plasma of the spontaneously hypertensive rats: expanding the model of neuroendocrine integration,” Behavioural Brain Research, vol. 230, no. 2, pp. 423–427, 2012.
- M. A. Samuels, “The brain-heart connection,” Circulation, vol. 116, no. 1, pp. 77–84, 2007.
- J. F. Thayer and J. F. Brosschot, “Psychosomatics and psychopathology: looking up and down from the brain,” Psychoneuroendocrinology, vol. 30, no. 10, pp. 1050–1058, 2005.
- J. F. Thayer and R. D. Lane, “The role of vagal function in the risk for cardiovascular disease and mortality,” Biological Psychology, vol. 74, no. 2, pp. 224–242, 2007.
- M. J. Hilz, O. Devinsky, H. Szczepanska, J. C. Borod, H. Marthol, and M. Tutaj, “Right ventromedial prefrontal lesions result in paradoxical cardiovascular activation with emotional stimuli,” Brain, vol. 129, no. 12, pp. 3343–3355, 2006.
- M. Ramírez, I. Prieto, F. Alba, F. Vives, I. Banegas, and M. de Gasparo, “Role of central and peripheral aminopeptidase activities in the control of blood pressure: a working hypothesis,” Heart Failure Reviews, vol. 13, no. 3, pp. 339–353, 2008.
- I. Prieto, F. Hermoso, M. De Gasparo et al., “Aminopeptidase activity in renovascular hypertension,” Medical Science Monitor, vol. 9, no. 1, pp. BR31–BR36, 2003.
- G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, London, UK, 4th edition, 1998.
- A. B. Segarra, J. I. Ruiz-Sanz, M. B. Ruiz-Larrea et al., “The profile of fatty acids in frontal cortex of rats depends on the type of fat used in the diet and correlates with neuropeptidase activities,” Hormone and Metabolic Research, vol. 43, no. 2, pp. 86–91, 2011.
- W. C. De Mello and E. D. Frohlich, “On the local cardiac renin angiotensin system. Basic and clinical implications,” Peptides, vol. 32, no. 8, pp. 1774–1779, 2011.
- J. Patil, S. Stucki, J. Nussberger et al., “Angiotensinergic and noradrenergic neurons in the rat and human heart,” Regulatory Peptides, vol. 167, no. 1, pp. 31–41, 2011.
- G. O. A. Naik, G. W. Moe, and P. W. Armstrong, “Specific and non-specific measurements of tissue angiotensin II cascade members,” Journal of Pharmaceutical and Biomedical Analysis, vol. 24, no. 5-6, pp. 947–955, 2001.
- B. K. Slinker, Y. Wu, A. J. Brennan, K. B. Campbell, and J. W. Harding, “Angiotensin IV has mixed effects on left ventricle systolic function and speeds relaxation,” Cardiovascular Research, vol. 42, no. 3, pp. 660–669, 1999.
- A. L. Albiston, S. G. McDowall, D. Matsacos et al., “Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase,” Journal of Biological Chemistry, vol. 276, no. 52, pp. 48623–48626, 2001.
- A. L. Albiston, R. N. Fernando, H. R. Yeatman et al., “Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory,” Neurobiology of Learning and Memory, vol. 93, no. 1, pp. 19–30, 2010.
- V. Pham, A. L. Albiston, C. E. Downes et al., “Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice,” Journal of Neurotrauma, vol. 29, no. 6, pp. 1243–1248, 2012.
- B. Stragier, D. De Bundel, S. Sarre et al., “Involvement of insulin-regulated aminopeptidase in the effects of the renin-angiotensin fragment angiotensin IV: a review,” Heart Failure Reviews, vol. 13, no. 3, pp. 321–337, 2008.
- Y. D. Li, E. R. Block, and J. M. Patel, “Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation,” American Journal of Physiology, vol. 283, no. 4, pp. L707–L716, 2002.
- J. W. Wright and J. W. Harding, “Brain renin-angiotensin-A new look at an old system,” Progress in Neurobiology, vol. 95, no. 1, pp. 49–67, 2011.
- M. Ramírez, I. Banegas, A. B. Segarra, et al., “Bilateral distribution of oxytocinase activity in the medial prefrontal cortex of spontaneously hypertensive rats with experimental hemiparkinsonism,” in Mechanisms in Parkinson's Disease—Models and Treatments, J. Dushanova, Ed., InTech, 2012.
- S. Petersen, M. Bähr, and J. Eckel, “Insulin-dependent regulation of Glut4 gene expression in ventricular cardiomyocytes: evidence for a direct effect on Glut4 transcription,” Biochemical and Biophysical Research Communications, vol. 213, no. 2, pp. 533–540, 1995.
- F. Randsbaek, H. H. Kimose, T. Bjerre, U. Møldrup, H. E. Bøtker, and T. T. Nielsen, “Captopril-induced glutamate release at the start of reperfusion after cold cardioplegic storage of pig hearts,” Journal of Thoracic and Cardiovascular Surgery, vol. 119, no. 5, pp. 1030–1038, 2000.
- I. Banegas, I. Prieto, F. Vives et al., “Asymmetrical response of aminopeptidase A and nitric oxide in plasma of normotensive and hypertensive rats with experimental hemiparkinsonism,” Neuropharmacology, vol. 56, no. 3, pp. 573–579, 2009.
- I. Banegas, I. Prieto, F. Vives et al., “Lateralized response of oxytocinase activity in the medial prefrontal cortex of a unilateral rat model of Parkinson's disease,” Behavioural Brain Research, vol. 213, no. 2, pp. 328–331, 2010.
- I. Banegas, I. Prieto, A. B. Segarra et al., “Blood pressure increased dramatically in hypertensive rats after left hemisphere lesions with 6-hydroxydopamine,” Neuroscience Letters, vol. 500, no. 2, pp. 148–150, 2011.
- J. T. Chi, H. Y. Chang, G. Haraldsen et al., “Endothelial cell diversity revealed by global expression profiling,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 19, pp. 10623–10628, 2003.
- J. Bohlender and H. Imboden, “Angiotensinergic neurotransmission in the peripheral autonomic nervous system,” Frontiers in Bioscience, vol. 17, no. 7, pp. 2419–2432, 2011.
- A. L. M. Swislocki, T. L. Kinney Lapier, D. T. Khuu, K. Y. Fann, M. Tait, and K. J. Rodnick, “Metabolic, hemodynamic, and cardiac effects of captopril in young, spontaneously hypertensive rats,” American Journal of Hypertension, vol. 12, no. 6, pp. 581–589, 1999.
- J. J. Braszko, W. Karwowska-Polecka, D. Halicka, and P. R. Gard, “Captopril and enalapril improve cognition and depressed mood in hypertensive patients,” Journal of Basic and Clinical Physiology and Pharmacology, vol. 14, no. 4, pp. 323–343, 2003.
- C. Demers, A. Mody, K. K. Teo, and R. S. McKelvie, “ACE inhibitors in heart failure: what more do we need to know?” American Journal of Cardiovascular Drugs, vol. 5, no. 6, pp. 351–359, 2005.
- S. M. Oppenheimer, A. Gelb, J. P. Girvin, and V. C. Hachinski, “Cardiovascular effects of human insular cortex stimulation,” Neurology, vol. 42, no. 9, pp. 1727–1732, 1992.
- F. Colivicchi, A. Bassi, M. Santini, and C. Caltagirone, “Cardiac autonomic derangement and arrhythmias in right-sided stroke with insular involvement,” Stroke, vol. 35, no. 9, pp. 2094–2098, 2004.
- H. K. Naver, C. Blomstrand, and B. Gunnar Wallin, “Reduced heart rate variability after right-sided stroke,” Stroke, vol. 27, no. 2, pp. 247–251, 1996.
- R. T. F. Cheung and V. Hachinski, “Cardiac effects of stroke,” Current Treatment Options in Cardiovascular Medicine, vol. 6, no. 3, pp. 199–207, 2004.
- L. A. Campos, M. Bader, and O. C. Baltatu, “Brain Renin-Angiotensin system in hypertension, cardiac hypertrophy, and heart failure,” Frontiers in Physiology, vol. 2, article 115, 2011.
- D. I. Barry, O. B. Paulson, and J. O. Jarden, “Effects of captopril on cerebral blood flow in normotensive and hypertensive rats,” American Journal of Medicine, vol. 76, no. 5, pp. 79–85, 1984.
- K. H. Berecek, K. A. Kirk, S. Nagahama, and S. Oparil, “Sympathetic function in spontaneously hypertensive rats after chronic administration of captopril,” American Journal of Physiology, vol. 252, no. 4, part 2, pp. H796–H806, 1987.
- G. Vallortigara, “The evolutionary psychology of left and right: costs and benefits of lateralization,” Developmental Psychobiology, vol. 48, no. 6, pp. 418–427, 2006.
- A. Samara and G. T. Tsangaris, “Brain asymmetry: both sides of the store,” Expert Review of Proteomics, vol. 8, no. 6, pp. 693–703, 2011.
- M. E. Rentería, “Cerebral asymmetry: a quantitative, multifactorial, and plastic brain phenotype,” Twin Research and Human Genetics, vol. 15, no. 3, pp. 401–413, 2012.