Review Article
Resistant Hypertension and Obstructive Sleep Apnea
Table 1
Effects of continuous positive airway pressure therapy on resistant hypertension.
| Study | Study design, population | Sample size () | Intervention | Results |
|
Logan et al., 2003 [6] | Prospective observational, refractory HTN, AHI ≥ 10 | 11 | CPAP for 2 nights in sleep lab and then 2 months | CPAP used BP acutely and over two months |
|
Martinez -Garcia et al., 2007 [7] | Prospective observational, difficult to treat HTN, AHI ≥ 15 | 33 | CPAP for 2 months | CPAP systolic BP, particularly at night |
|
Dernaika et al., 2009 [8] | Retrospective chart review, observational, HTN, AHI > 5 | 98 | CPAP therapy for 1 year, controlled HTN ( 56) versus resistant HTN ( 42) | CPAP permitted deescalation of anti-HTN treatment in 71% of subjects with resistant HTN, no significant change in controlled HTN |
|
Lozano et al., 2010 [9] | Prospective randomized controlled parallel trial, resistant HTN, AHI ≥ 15 | 75 | CPAP ( 38) versus conventional treatment ( 37) | CPAP for 3 months led to in 24 hr ABP in patients who used CPAP > 5.8 hr/night |
|
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24 hr ABP: 24-hour ambulatory blood pressure monitoring, AHI: apnea hypopnea index, BP: blood pressure, CPAP: continuous positive airway pressure, HTN: hypertension.
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