Research Article

DNA Damage and Augmented Oxidative Stress in Bone Marrow Mononuclear Cells from Angiotensin-Dependent Hypertensive Mice

Figure 4

Effects of renovascular hypertension on oxidative stress in bone-marrow-mononuclear cells (BM-MNCs). (a) contains representative histograms of intracellular oxidation of dihydroethidium (DHE) to ethidium by BM-MNC from a hypertensive (2K1C) and a normotensive (Sham) mouse as evaluated by flow cytometry. The bar graph summarizes the median fluorescence intensity (MFI) values of DHE-loaded BM-MNC from 2K1C ( ) and Sham ( ) mice. Values are the medians ± coefficient of variation. ** versus the Sham group (Mann-Whitney test).
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(a)
305202.fig.004b
(b)