Clinical Implications of the Change in Glomerular Filtration Rate with Adrenergic Blockers in Patients with Morning Hypertension: The Japan Morning Surge-1 Study

Table 2

Blood pressure and renal functional parameter changes during 6 months.

	Added treatment group (𝑛=308)		Control group (𝑛=303)
	baseline	6th month	baseline	6th month
Morning SBP (mmHg)	153±13	140±15^∗∗,††	151±15	146±16^∗∗
Morning DBP (mmHg)	82±10	73±10^∗∗,††	82±11	80±11^∗∗
Evening SBP (mmHg)	140±14	133±15^∗∗,††	140±17	137±15^∗∗
Evening DBP (mmHg)	75±10	69±10^∗∗,††	76±11	74±10^∗∗
Estimated GFR (mL/min/1.73 m^2)	84.1±21.1	80.3±19.3^∗∗	82.0±18.9	80.9±19.9^∗
Creatinine (mg/dL)	0.79±0.27	0.82±0.29^∗∗	0.80±0.25	0.82±0.28^∗
UACR (mg/gCr)	23.0 (11.4–63.1)	14.7(8.2−−35.8)^∗∗,†	21.0 (10.7–53.2)	19.4 (11.5–53.6)

Data are shown as the means ± SD. UACR is expressed as the median values (25% value–75% value). BP: blood pressure; SBP: systolic blood pressure; DBP: diastolic blood pressure; GFR: glomerular filtration rate; UACR: urinary albumin/creatinine ratio.
 ^∗𝑃<0.05, ^∗∗𝑃<0.001 versus baseline in each group: ^†𝑃<0.05, ^††𝑃<0.001 versus the 6th month in the control group.