Study (Author and Ref) Subjects Marker Results Comments
López-Jaramillo, et al. [27 ] 325 schoolchildren (mean age, 10.0 years) from Colombia CRP Mean (mg/dL) ± SD Boys: 1.2 ± 2.6 Girls: 1.5 ± 2.0 BMI: 15 0.6 ± 0.9 BMI: 17 1.1 ± 2.2 BMI: 21 1.9 ± 3.7 CRP levels correlate significantly with BMI. (
). Gillum [83 ] 996 Mexican American children aged 6–11 years. CRP Detectable CRP was seen in 34.7% of overweight children but only 6.8% of other children (
, RR = 5.12, 95% CI: 3.32–7.90). CRP levels correlate significantly with BMI. (
). Visser et al. [84 ] 3512 American children (8 to 16 years of age). CRP Percentile value CRP (mg/dL) CRP (4–11 years of age: >0.37 mg/dL for boys >0.68 mg/dL for girls Based on the BMI For overweight girls: 5.59 (95% CI: 2.20–14.22) For overweight boys: 6.12 (95% CI: 1.23–30.52) CRP levels correlate significantly with BMI. (
). Cook et al. [28 ] 699 (10 to 11 years of age) multiethnic study in children. CRP Median mg/L All groups: 0.15 (IQ 0.06–0.47) South Asian: 2.40 (1.42, 4.04) Other: 0.82 (0.35, 1.87) CRP was strongly related to adiposity (95% CI, 155–439%) and was higher in South Asian children. Ford [29 ] 3348 White, Black and Mexican-American US children and young adults. National Health and Nutrition Examination Survey, 1999-2000, CRP Median White: 1.6 mg/L Black: 1.7 mg/L Mexican-American: 1.5 mg/L Other: 1.8 mg/L No significant differences between ethnicities.
Aeberli et al. [30 ] 33 Swiss children (6 to 14 years of age). Normal-weight (
), overweight (
), and obese (
) CRP CRP median (mg/dL) IL-6 (pg/mL) TNF-α (pg/mL) Overweight: 0.03 (0.01–0.42) Obese: 0.10 (0.03–0.23) CRP, IL-6 increased significantly (
) with increasing adiposity, independent of age. IL-6 Overweight: 0.34 (0.05–1.81) Obese: 0.41 (0.14–2.00) TNF-α Overweight: 6.3 (4.2–11.8) Obese: 7.2 (4.1–21.8) Weiss et al. [85 ] 439 White, Black and Hispanic, obese, overweight and nonobese American children and adolescents. CRP Mean CRP (mg/dL), IL-6 (pg/mL) Blacks moderately obese: 0.13 Severely obese: 0.32 Whites moderately obese: 0.12 Severely obese: 0.31 Hispanics moderately obese: 0.13 Severely obese: 0.35 Interleukin-6 and CRP were significantly related to the degree of obesity (
) IL-6 Blacks moderately obese: 1.89 Severely obese: 2.36 Whites moderately obese: 1.59 Severely obese: 1.80 Hispanics moderately obese: 2.07 Severely obese: 3.09 Vikram et al. [86 ] 62 Indian adolescents CRP Mean (mg/dL) ± SD Normal weight: 2.5 ± 2.7 Overweight: 4.1 ± 2.4 CRP levels correlate significantly with BMI (
).