Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT

Table 1

Genetic variants analyzed.

SNP rs number	Gene name	Gene symbol	Alleles
1799752	Angiotensin I-converting enzyme	ACE	Insertion/deletion
4363	Angiotensin I-converting enzyme	ACE	A/G
4291	Angiotensin I-converting enzyme	ACE	A/T
4343	Angiotensin I-converting enzyme	ACE	A/G
4961	Alpha adducin	ADD1	G/T
1042713	Beta-2-adrenergic receptor	ADRB2	G/A
1042714	Beta-2-adrenergic receptor	ADRB2	C/G
1800888	Beta-2-adrenergic receptor	ADRB2	C/T
5050	Angiotensin I; angiotensinogen	AGT	A/C
5051	Angiotensin I; angiotensinogen	AGT	A/G
699	Angiotensin I; angiotensinogen	AGT	C (thr)/T (met)
5186	Angiotensin receptor I	AGTR1	A/C
1492078	Angiotensin receptor I	AGTR1	A/G
275653	Angiotensin receptor I	AGTR1	T/C
676210	Apolipoprotein B	APOB	C/T
1042031	Apolipoprotein B	APOB	G/A
5742905	Cystathionine-beta-synthase	CBS	Ile/thr
1799963	Coagulation factor II	F2	G/A
6025	Coagulation factor V	F5	G/A
6046	Coagulation factor VII	F7	G/A
5742910	Coagulation factor VII	F7	Insertion/deletion
7981123	Coagulation factor VII	F7	G/T
762637	Coagulation factor VII	F7	G/A
1801020	Coagulation factor XII	F12	C/T
5982	Coagulation factor Xll1, Al subunit	F13	C/T
5985	Coagulation factor Xll1, Al subunit	F13	C/T
1800790	Fibrinogen, B beta polypeptide	FGB	G/A
7121	Guanine nucleotide-binding protein, alpha-stimulating polypeptide 1	GNAS	T/C
5443	Guanine nucleotide-binding protein, BETA-3	GNB3	C/T
6065	Platelet glycoprotein Ib (alpha polypeptide)	GP1BA	C/T
4069688	Platelet glycoprotein Ib (alpha polypeptide)	GP1BA	G/T
2243093	Platelet glycoprotein Ib (alpha polypeptide)	GP1BA	T/C
1024323	G protein-dependent receptor kinase 4	GRK4/GPRK2L	C/T
1129292	G protein-dependent receptor kinase 4	GRK4/GPRK2L	C/T
2960306	G protein-dependent receptor kinase 4	GRK4/GPRK2L	G/T
1799969	Intercellular adhesion molecule 1	ICAM 1	G/A
1062535	Integrin, alpha-2	ITGA2	G/A
5918	Integrin, beta-3	ITGB3	T/C
328	Lipoprotein lipase	LPL	C/G
1041981	Lymphotoxin-alpha	LTA	C/A
1799750	Matrix metalloproteinase 1	MMP1	1G/2G
243865	Matrix metalloproteinase 2	MMP2	C/T
3025058	Matrix metalloproteinase 3	MMP3	5A/6A
11568818	Matrix metalloproteinase 7	MMP7	A/G
11568819	Matrix metalloproteinase 7	MMP7	C/T
2664538	Matrix metalloproteinase 9	MMP9	A/G
2274756	Matrix metalloproteinase 9	MMP9	G/A
2276109	Matrix metalloproteinase 12	MMP12	A/G
652438	Matrix metalloproteinase 12	MMP12	A/G
1801131	Methylenetetrahydrofolate reductase	MTHFR	A/C
1801133	Methylenetetrahydrofolate reductase	MTHFR	C/T
1799983	Nitric oxide synthase 3	NOS3	G/T
3918226	Nitric oxide synthase 3	NOS3	C/T
1800779	Nitric oxide synthase 3	NOS3	A/G
5065	Natriuretic peptide precursor A	NPPA	T/C
5063	Natriuretic peptide precursor A	NPPA	G/A
7242	Plasminogen activator inhibitor 1	PAI1/SERPINE1	T/G
1799768	Plasminogen activator inhibitor 1	PAI1/SERPINE1	5G/4G
27727	Phosphodiesterase 4D	PDE4D	A/G
40512	Phosphodiesterase 4D	PDE4D	A/G
10074908	Phosphodiesterase 4D	PDE4D	A/G
702553	Phosphodiesterase 4D	PDE4D	T/A
12188950	Phosphodiesterase 4D	PDE4D	G/A
6450512	Phosphodiesterase 4D	PDE4D	T/C
153031	Phosphodiesterase 4D	PDE4D	A/G
27653	Phosphodiesterase 4D	PDE4D	C/A
456009	Phosphodiesterase 4D	PDE4D	C/T
705379	Paraoxonase I	PON1	C/T
6681776	Renin	REN	G/A
2368564	Renin	REN	C/T
5742912	Sodium channel, nonvoltage-gated 1, alpha subunit	SCNNIA	T/C
2228576	Sodium channel, nonvoltage-gated 1, alpha subunit	SCNNIA	G/A
5361	Selectin E	SELE	A/C
5355	Selectin E	SELE	C/T
361525	Tumor necrosis factor	TFN	G/A
673	Tumor necrosis factor	TFN	G/A
1800629	Tumor necrosis factor	TFN	G/A
1800750	Tumor necrosis factor	TFN	G/A