Extreme Elevations in Blood Pressure and All-Cause Mortality in a Referred CKD Population: Results from the CRISIS Study

Table 2

Hazard ratio for death for baseline blood pressure variables.

	12-month mortality		Overall mortality
	Hazard ratio (95% confidence interval)	𝑃	Hazard ratio (95% confidence interval)	𝑃
Systolic blood pressure	Does not reach sufficient statistical; significance for inclusion in model		1.003 (1.0–1.007)	0.007
Diastolic blood pressure	1.02 (0.99–1.04)	0.09	0.98 (0.97–0.99)	<0.001
Target blood pressure (𝑛=722)	Referent		Referent
Elevated blood pressure (𝑛=892)	1.26 (0.7–2.2)	0.40	0.86 (0.7–1.0)*	0.06
Extreme hypertension (𝑛=77)	2.40 (0.9–6.7)	0.09	0.94 (0.7–1.3)*	0.9
Estimated glomerular filtration rate (mL/min/1.73 m^2)	0.98 (0.97–1.0)	0.06
Hemoglobin (g/dL)	0.96 (0.95–0.98)	<0.0001
Angiotensin blockade	0.58 (0.3–0.9)	0.05
Statin	0.55 (0.31–0.97)	0.04
Myocardial infarction	3.70 (2.2–6.3)	<0.0001
Stroke or transient ischemic attack	2.15 (1.2–3.8)	0.009
Diabetes mellitus	1.51 (0.9–2.6)	0.1
Smoking history	1.82 (1.0–3.5)	0.06

Data are presented as hazard ratio (95% confidence interval).
Results for continuous variables are presented per 1 unit increment.
Angiotensin blockade defined as prescription of angiotensin converting enzyme inhibitor or angiotensin II receptor blocker.
Smoking history defined as current or previous smoking.
 *does not reach statistical significance in multivariate analysis—value presented is unadjusted hazard ratio.