Pathophysiology of Vascular Remodeling in Hypertension

Figure 3

Associated intracellular cascades to physiopathology of vascular remodeling. In FFHR experimental model, the route associated with the satellite receptor and the IGFR subunit associated with NAD(P)H oxidase are the most important pathophysiological mechanisms. Also, the oxidative stress pathway stimulated by angiotensin activates redox-sensitive inflammatory molecules such as AP-1 and NF-κB, which amplify vascular inflammatory response.