Review Article
Cardiovascular Risk Factors and Chronic Kidney Disease—FGF23: A Key Molecule in the Cardiovascular Disease
Table 1
Klotho expression in the aorta.
| Author | Species | Klotho expression | Major findings | Effect of FGF23 on vascular calcification | References |
| Mitani | Rat | Negative | Klotho was expressed in the kidney but not in aorta or heart. | Not evaluated | [69] |
Nakano-Kurimoto | Human | Positive (mRNA) | Klotho was expressed in human coronary artery smooth muscle cells but not in endothelial cells. | Not evaluated | [70] | Donate-Correa | Human | Positive (mRNA) | Klotho was expressed in human thoracic aorta and thrombus material from patients with acute coronary syndrome. | Not evaluated | [71] | Lim | Human | Positive | Klotho was expressed in human aorta or human aortic smooth muscle cells. Calcitriol restored the Klotho expression, decreased by uremic toxin. | FGF23 had an anticalcification effect in the presence of calcitriol. | [72] | Scialla | Human | Negative | FGF23 and Klotho were not detected in human or mouse VSMCs. | FGF23 had no effect on vascular calcification in human vascular smooth muscle cells or mouse aortic rings. | [73] | Lindberg | Mouse | Negative | Klotho expression was undetectable by immunohistochemistry and Western blot analysis. | FGF23 had no effect on vascular calcification in bovine vascular smooth muscle cells. | [74] | Fang | Mouse (ldlr−/−) | Positive | Early CKD reduced vascular Klotho and FGF23 expression. | Not evaluated | [75] | Jimbo | Rat | Positive | Klotho expression was detected in the aorta of normal and uremic rats. | FGF23 accelerated vascular calcification in Klotho-overexpressed rat VSMCs and rat aortic rings. | [76] |
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