Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3

Table 3

Protein-DNA contacts (hydrogen bonds) observed in STAT3-DNA allele C/allele T.

STAT3-DNA allele C			STAT3-DNA allele T
Acceptor	Residue contact	Description	Acceptor	Residue contact	Description
T5	Gln344 NE2	Unfavorable contact	T4	Gln344 NE2	Unfavorable contact
T6	His332 NE2; Lys340 NZ	Unfavorable contact	T5	Gln344 N	Unfavorable contact
A7	Lys340 NZ	Unfavorable contact	T6	Lys340 NZ	Unfavorable contact
A13	Arg417 NH1	Unfavorable contact	T14	Asp427 N; Ala428 N	Unfavorable contact
C14	Arg423 NE	Unfavorable contact	T27	Thr433 OG1; Gln469 NE2	Unfavorable contact
G15	Arg423 NH1	Unfavorable contact	G29	Arg417 NE,  NH2	Favorable contact
A28	Arg417 NH2	Unfavorable contact	T30	Arg417 NH2	Unfavorable contact
T27	Arg382 NH1; Val432; Gln469 NE2	Unfavorable contact