Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

Figure 4

Representative traces of arterial pressure after intracerebroventricular (icv) administration of aminopeptidase A (APA) following pretreatment with telmisartan. Thirty minutes prior to the icv administration of 800 ng of APA, Wistar-Kyoto rats received icv administration of vehicle () or 80 g of telmisartan () in a conscious, unrestrained state. Icv administration of telmisartan or vehicle did not change the baseline MAP. Pretreatment with telmisartan significantly attenuated the pressor response of APA. Arrow: time for APA administration.