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Hypertension and Cerebral Blood Flow

Call for Papers

Hypertension is a leading risk factor for cerebrovascular disease, cognitive dysfunction, dementia, and stroke. Hypertension alters the structure of cerebral vessels, reduces resting cerebral blood flow (CBF) in selected brain regions, and impairs the main mechanisms that control CBF. Impaired cerebrovascular reactivity in hypertensive patients has been associated with cognitive dysfunction and dementia. Cognitive impairment is a major cause of reduced quality of life amongst the elderly. The Canadian Study of Health and Aging stated that, within 5 years, approximately one-half of those with cognitive impairment develop dementia. Recently, it has been demonstrated that subjects with hypertension have an increased risk of conversion from cognitive dysfunction to dementia. However, conflicting data exist about the extent of beneficial effects of antihypertensive drugs on the development of dementia.

We invite investigators to contribute original articles, as well as review articles, that seek to understand how hypertension alters cerebral blood flow and how these effects are related to vascular cognitive impairment, vascular dementia, and neurodegenerative diseases. This issue will focus on cerebrovascular effects that are more subtle than stroke. Potential topics include, but are not limited to:

  • Mechanisms underlying cerebrovascular dysfunction in hypertension (oxidative stress, inflammation, renin-angiotensin system, endothelial integrity, vascular remodeling, and tone)
  • Hypertension and cerebral small vessel diseases
  • Cerebrovascular reactivity in hypertension in the context of psychological and physiological stress, arterial stiffness, preeclampsia, and eclampsia as well as aging
  • Effects of hypertension on CBF and subsequent effects on brain structure and function
  • Effects of antihypertensive drugs on CBF and on brain structure and function
  • Hypertension and brain imaging

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/ijht/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ijht/hcbf/ according to the following timetable:

Manuscript DueFriday, 6 September 2013
First Round of ReviewsFriday, 29 December 2013
Publication DateFriday, 24 January 2014

Lead Guest Editor

  • Hélène Girouard, Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada

Guest Editors

  • Marilyn Cipolla, Department of Neurological Sciences, University of Vermont, Burlington, VT 05405, USA
  • J. Richard Jennings, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
  • Christopher Sobey, Department of Pharmacology, Faculty of Medicine, Nursing & Health Sciences, Monash University, VIC 3800, Australia