NOD1-Mediated Mucosal Host Defense against Helicobacter pylori

Figure 2

Molecular mechanisms of NOD1-mediated mucosal host defense against H. pylori. Infection of gastric epithelial cells with H. pylori activates type I IFN signaling, which leads to the generation of protective Th1 responses. H. pylori infection induces hBD2 production by epithelial cells mainly via TLR signaling pathways.