Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights
Figure 4
Effect of SR140333 administration, either 30 minutes before or 1 hour after CLP, on lung (a) NK-1R and (b) NK-2R mRNA levels. Results shown are the mean S.E.M ( 6–9 in each group). “Vehicle + CLP” and “SR140333 + CLP” represent the groups that received vehicle and SR140333 treatment, respectively, commencing 30 minutes prior to CLP. “CLP + vehicle” and “CLP + SR140333” represent the groups that received vehicle and SR140333 treatment, respectively, 1 hour after CLP. when vehicle-treated CLP animals were compared with sham group animals. CLP: cecal ligation and puncture; IOD: integrated optical density; NK-1(2)R: neurokinin-1(2) receptor.
