Toll-Like Receptors and Myocardial Inflammation

Figure 6

TLR2^−/− mice have improved cardiomyocyte function after polymicrobial sepsis. Wild-type (WT) and TLR2^−/− mice underwent sham or cecum ligation and puncture (CLP) procedures. Twenty-four hours later, the hearts were harvested and cardiomyocytes were isolated. A, Representative tracing of sarcomere shortening and Ca²⁺ transients in cardiomyocytes isolated from WT (a, b) and TLR2^−/− (c, d) mice subjected to either sham (a, c) or CLP (b, d) surgeries. B, Accumulated data of sarcomere shortening and Ca²⁺ transients. Each error bar represents mean ± SE. The data in each group were recorded from 16 to 27 single adult cardiomyocytes isolated from more than four mice. ^∗𝑃<0.05 versus WT sham; ^∗∗𝑃<0.01 versus WT CLP; ^‡𝑃<0.001 versus WT sham. KO, knockout (TLR2^−/−). (Zou et al., [124], used with permission).