International Journal of Inflammation

Review Article

Toll-Like Receptors and Myocardial Inflammation

Table 2

Role of TLRs in myocardial inflammation and injury after acute ischemia/reperfusion.
Mice strainsI/R modelsI/R protocolsMICardiac functionInflammation
TLRsNF-κB activityCytokine production Myocardial neutrophil infiltrationEC dysfunction/ROS ↑Ref.
Myocardium Serum
mRNAProtein
TLR2TLR2−/−, TIRAP−/−ex vivo30′ I/60′ R↑ TNFα, IL-1β[86]
TLR2−/−in vivo30′ I/1 h R↓IL-1β↓↓[87]
TLR2−/− chimeric, WT with Anti-TLR2in vivo30′ I/24 h R↓↑ TNFα, IL-1β, IL-10, M-CSF↓[88]
TLR2−/−, WT with Anti-TLR2in vivo20′ I/24 h R↓↓[89]
TLR4C57BL/10 ScCr C3H/HeJin vivo60′ I/24 h R↓↓[90]
C3H/HeJin vivo60′ I/2 h R↓↓ TNFα, IL-1β, MCP-1, IL-6[91]
WT with Eritoranin vivo30′ I/2 h R↓ TNFα, IL-1β, MCP-1, IL-6, MIP-1, MIP-2[92]
C3H/HeJin vivo60′ I/2 h, 24 h R↓NS TNFα, IL-1β, IL-6 TNFα, IL-1β, IL-6[93]
C57BL/10 ScCr C3H/HeJex vivo20′ I/60′ R↑↓ TNFα, IL-1β[94]
WT with Anti-HSC70ex vivo20′ I/60′ R↑ TNFα, IL-1β, IL-6 TNFα, IL-1β, IL-6[95]
C3H/HeJex vivoHSC70↑↓ TNFα, IL-1β, IL-6 TNFα, IL-1β, IL-6[95]
C3H/HeJex vivo20′ I/60′ R KC, MCP-1 KC, MCP-1 perfused NE↓[96]
C3H/HeJin vivotransplantation 2 h I/3 h, 24 h R↓ TNFα, IL-1β, IL-6, ICAM-1 TNFα, IL-1β, IL-6, ICAM-1↓[97]
MyD88WT with Ad-dnMyD88in vivo45′ I/4 h R↓↓[98]
MyD88−/−in vivo30′ I/24 h R↓↑ MCP-1, KC, ICAM-1↓[99]
MyD88−/−ex vivo20′ I/40′ RNSNS[99]
MyD88−/− chimericin vivo30′ I/24 h R↓ NS↓[100]
OthersCD14−/−, MyD88−/−, Trif−/−in vivotransplantation 2 h I/3 h, 24 h R↓ TNFα, IL-1β, IL-6, ICAM-1 TNFα, IL-1β, IL-6, ICAM-1↓[101]
NS: no significant difference.