Tissue Factor, Blood Coagulation, and Beyond: An Overview

Figure 1

TF structure. The 46-kDa membrane-bound single polypeptide chain consists of extracellular, transmembrane, and cytoplasmic domains. There are 2 intrachain disulfide bridges (Cys49-Cys57 and Cys186-Cys209, shown in blue) in the extracellular domain where it also contains FVII/FVIIa binding domain (see text) initiating signaling cascade for the extrinsic blood coagulation (Figure 2, left panel). There are three serine residues (shown in red) in the cytoplasmic domain for undergoing phosphorylation. *Denotes 3 proposed glycosylation sites at Asn11, 124, and 137. Adopted and modified from [3].