Table 1: Targeting TF-initiated coagulation and signaling consequence for easing clinical events.

Strategy and agent Antagonism against TF suppression  HMGCR inhibitors Inflammation; thrombosis; miscarriage; APS; cancer growth  COX inhibitors Inflammation, APS; thrombosis; miscarriage; cancers  Vitamin D3 APS; thrombosis; cancer  Amiodarone AT; arrhythmia  Ethyl pyruvate Inflammation; coagulation  NO Platelet activation; thrombosis  Indobufen AT  Hydroxyurea Thrombosis  RNAi Metastasis  DMSO ACS  Adiponectin Atherogenesis; diabetes; ACS  Hairpin ribozym Thrombosis; I/R injury  TF sh RNA Breast cancer growth/angiogenesis  Metformin Diabetes II  Liver X receptor agonists AT  Paclitoxel Cancers  Antisense TF ODN I/R injury  ACE inhibitors MI  Nicotinamide Sepsis; DIC; coagulation; inflammation  PPARα activation Obesity; diabetes  Guggulsterone Inflammation; AT  ATRA Leukemia; CHD  Phenolics/resveratrol CHD FVIIa inhibition  BcX-3607 Thrombosis; inflammation  FVIIai Colorectal metastasis; inflammation; thrombosis/MI  rNAPc2 Coagulation; inflammation; angiogenesis; tumor growth  Hemextin AB Coagulation  BMS593214 AT; VT  PN7051 Thrombosis  PHA-798 Thrombosis  FFR-rFVIIa Inflammation; thrombosis; metastasis FXa inhibition  Fondaparinux DVT; VTE; PE  Enoxaparin Inflammation; AT; VT  WX-FX4 Metastasis/tumor growth/angiogenesis  DX-9065a Inflammation; platelet aggregation; DIC; tumor proliferation  TAK-442 Coagulation; VT  ZK-807834 Inflammation; AT; VT  Oral rivaroxaban AF; VTE  Oral GW 813893 Thrombosis  Oral BMB344577 Cancer proliferation  Oral apixaban Platelet aggregation  LMWH AVE5026 AT; VT; coagulation  Oral DU176b Thromboembolism; coagulation  Oral sulfanilamide Coagulation  Oral DPC423 Thrombosis  Oral YM-75466 Thrombosis  MCM09 Cancer metastasis  Oral BAY597939 Thromboembolism  Ixolaris Tumor growth; angiogenesis  NAP5 Coagulation  Tinzaparin Metastasis  SamOrg123781A AT  rTAP (rAST) Thrombosis; restenosis  Rivaroxaban Stroke; AF FIIa inhibition  FM-19 Platelet activation; ACS; tumor growth  Dabigatran etexilate Breast cancer progression  Argatroban DVT; VTE; tumor migration/metastasis  Heparin Inflammation; DVT; VTE; pregnancy loss; metastasis  Foypan Metastasis  Ximelagatran DVT; VTE; AT  Hirudins Inflammation; DVT; VTE; AT  Org 42675 AT PAR blockade  SCH 7979 Inflammation; platelet aggregation; I/R injury; cancer cell motility/metastasis/angiogenesis  RWJ 56110 Platelet aggregation; thrombosis  RWJ 58259 Platelet aggregation; vascular occlusion; neointimal thickness; restenosis; thrombosis  PAR-1 antibody Platelet aggregation  PAR-2 mAb Joint inflammation  ENMD-1068 Joint inflammation  P4pal DIC; thrombocytopenia; I/R injury  YD-3 Platelet aggregation  SFLLR Platelet aggregation  FR 171113 Platelet aggregation; AT  TH146 Platelet aggregation; thrombosis  FSLLRY-NH2  Inflammation Miscellaneous  TFPI Inflammation; pulmonary fibrosis; VT; pneumonia; RA; cancer; apoptosis  APC Inflammation; AT; VT; sepsis; metastasis; apoptosis  AT-III Inflammation; thrombosis; metastasis; angiogenesis  Dilazep Platelet aggregation; APS  CNTO 859 Tumor initiation/growth/angiogenesis  Anti-TF mAb Septic shock; DVT; AT/VT; miscarriage  Oral warfarin Inflammation; thrombosis; metastasis; tumor growth  n-3 FA Inflammation

APS: antiphospholipid syndrome; ACS: acute coronary syndromes; AF: atrial fibrillation; ATRA: all-trans retinoic acid; AT: arterial thrombosis; CHD: coronary heart disease; COX: cyclooxygynase; DIC: disseminated intravascular coagulation; DVT: deep vein thrombosis; HMGCR: HMGCoA reductase; MI: myocardial infarction; VT: venous thrombosis; VTE: venous thromboembolism; PE: pulmonary embolism; RA: rheumatoid arthritis; I/R injury, ischemia/reperfusion injury.